Position Summary:

The Research Associate will support Research and Development activities in the field of molecular biology, with a focus on the identification and verification of DNA methylation-based biomarkers and the development, optimization, and verification of epigenetic qPCR assays and ddPCR-based assays. The position involves the execution of laboratory experiments, processing of clinical study samples, analysis and documentation of experimental data, and support of laboratory quality and operational activities in a regulated environment.

Essential functions of the job include but are not limited to:

Perform laboratory activities in accordance with approved SOPs, work instructions, and experimental protocols with appropriate guidance.
Conduct laboratory experiments to support the identification and verification of DNA methylation-based biomarkers.
Support the development, optimization, verification, and transfer of (epigenetic) qPCR- and ddPCR-based assays.
Perform experimental quality control activities and support the qualification and release of plasmid standards and other critical reagents.
Receive, prepare, process, and document clinical trial samples in accordance with defined procedures and study requirements.
Perform epigenetic immune monitoring analyses, including bisulfite conversion and purification of DNA samples, qPCR analysis, data evaluation, and quality control.
Analyze, interpret, document, and communicate experimental results to project scientists and team members.
Identify technical issues, investigate deviations, and support troubleshooting and root cause analysis activities.
Prepare reagents, controls, and laboratory materials required for routine and development activities.
Operate and maintain laboratory automation and liquid handling systems.
Perform routine equipment checks, maintenance, calibration support, and associated documentation activities.
Maintain accurate, complete, and traceable laboratory records in accordance with applicable quality requirements.
Support the preparation, review, and revision of SOPs, work instructions, protocols, reports, and other controlled documents.
Participate in method evaluations, feasibility studies, and implementation of new laboratory technologies.
Collaborate with scientists, project managers, and laboratory personnel to meet project timelines and milestones.
Support laboratory organization, inventory management, ordering of consumables, and monitoring of laboratory supplies.
Perform all activities in accordance with applicable health, safety, quality, and data integrity requirements.
Contribute to inspection and audit readiness activities.

Qualifications:

Minimum Required:

Bachelor’s degree in molecular biology, Biology, Biochemistry, Biotechnology, Life Sciences, or a related scientific discipline.
Minimum of 2 years of relevant laboratory experience or an equivalent combination of education and experience.
Practical experience with molecular biology laboratory techniques.
Experience working with scientific procedures, protocols, and laboratory documentation.
Ability to communicate effectively in English, both written and verbal.
German language skills at a minimum B1 level.
Proficiency with Microsoft Office applications, particularly Excel and Word.

Other Required:

Ability to organize, prioritize, and manage multiple tasks simultaneously.
Structured, reliable, and quality-focused working style.
Ability to work effectively both independently and within a multidisciplinary team.
Good analytical and problem-solving skills.
Ability to evaluate experimental data and document results appropriately.
Willingness to continuously learn new methods, technologies, and quality system requirements.

Preferred:

Experience with DNA methylation analysis and bisulfite conversion methods.
Experience with qPCR and/or ddPCR technologies.
Experience processing and handling clinical trial samples.
Experience with assay development, optimization, verification, or validation.
Experience operating automated liquid handling systems.
Experience with Laboratory Information Management Systems (LIMS).
Familiarity with GraphPad Prism or other scientific data analysis software.
Experience working in a regulated or quality-controlled laboratory environment (e.g., GCP, GLP, ISO, CAP, CLIA, or equivalent).
Knowledge of cell biology and immunology concepts.
Experience supporting scientific reports, technical documentation, or publications.

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